AOD-9604
AOD-9604 is a modified fragment of human growth hormone (hGH) designed to selectively stimulate fat breakdown and preserve lean mass, without affecting insulin sensitivity or promoting general growth effects.
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AOD-9604 is a modified fragment of human growth hormone (hGH), specifically amino acids 176โ191, engineered to focus on fat metabolism without triggering the broader growth effects associated with full-length hGH. This peptide has become a popular tool in obesity and lipolysis research due to its ability to stimulate the breakdown of adipose tissue while preserving lean mass. Unlike hGH, AOD-9604 does not affect insulin sensitivity or IGF-1 levels, making it a unique candidate for selective fat-loss pathways.
โ Form: Lyophilized peptide
โ Purity: โฅ99%
โ Origin: Manufactured and tested in the USA
โ Certifications: Certificate of Analysis (COA) included with every order
AOD-9604 acts by:
โ Mimicking the lipolytic domain of hGH (176โ191 fragment)
โ Activating ฮฒ3-adrenergic receptors in adipose tissue
โ Stimulating fat breakdown (lipolysis) without growth-promoting effects
โ Increasing fat oxidation and energy expenditure
โ Minimizing interaction with IGF-1 pathways
โ Obesity and fat metabolism studies
โ Selective adipose tissue lipolysis models
โ Growth hormone-independent metabolic investigations
โ Lean mass preservation research
โ Exercise and body composition modulation
โ Non-anabolic alternative to hGH for metabolic studies
โ No effect on blood sugar, IGF-1, or lean mass
โ Excellent safety profile in preclinical models
โ Clear lipolytic effects in adipose-rich models
Each vial is:
โ Manufactured in a GMP-compliant U.S. facility
โ Accompanied by a Certificate of Analysis (COA)
โ Subjected to HPLC and mass spectrometry verification
โ Shipped from within the United States for quality control
โ Contents: 5mg of lyophilized AOD-9604 peptide
โ Appearance: White/off-white powder
โ Solubility: Sterile bacteriostatic water recommended
โ Storage: Store lyophilized vial at -20ยฐC; reconstituted solution stable up to 30 days when refrigerated
*For laboratory research use only. Not intended for human or veterinary use.*
โ This product is sold for research purposes only
โ Not for human consumption, injection, or diagnostic procedures
โ Must be handled by qualified professionals in accordance with institutional and governmental safety guidelines
AOD-9604 is a modified peptide fragment derived from human growth hormone (hGH), specifically the C-terminus (176โ191 sequence). It is researched for its potential to stimulate fat metabolism without the growth-promoting effects associated with full-length hGH.
AOD-9604 works by stimulating lipolysis (the breakdown of fat) and inhibiting lipogenesis (the formation of fat), primarily through interaction with beta-adrenergic receptors and hormone-sensitive lipase. It does not bind to GH receptors, making it selective for fat metabolism in research models.
Our AOD-9604 is supplied as a lyophilized powder in sterile, single-use vials. It is synthesized in the USA under strict GMP-like lab conditions and tested to ensure the highest standards of purity and stability.
Store the lyophilized vial at -20ยฐC, in a dry and light-protected environment. Once reconstituted, refrigerate between 2โ8ยฐC and use within your research teamโs stability timeline.
Shop Peptides Direct guarantees โฅ98% purity, validated using HPLC and Mass Spectrometry. Every order includes a batch-specific Certificate of Analysis (COA) for full transparency.
Yes. While AOD-9604 is stable in our standard packaging, cold-chain shipping is available upon request for researchers who require added temperature control during transit.
In research settings, AOD-9604 is sometimes studied alongside metabolic peptides like MOTS-c or Tesofensine to evaluate complementary effects on fat metabolism. All use must remain within the guidelines of responsible research practices.
Go to our Lab Test Results page, select AOD-9604 from the dropdown, and provide your email address. Youโll receive the COA for your batch within minutes.
We provide U.S.-manufactured, โฅ98% pure AOD-9604 with full lab testing, a Price Match Guarantee, and fast fulfillment. Each vial includes a COA, and our support team is always ready to assist your research needs.
AOD-9604 (2 mg & 5 mg Vials) Dosage Protocol
Quickstart Highlights
AOD-9604 dosage protocols leverage this synthetic 16โaminoโacid fragment (TyrโhGH 177โ191) to support lipolysis (fat breakdown) and inhibit lipogenesis (fat storage) without elevating IGFโ1 levels or causing insulin resistance[1][2]. Clinical trials have demonstrated that AODโ9604 exhibits a placeboโlike safety profile in obese adults, making it a wellโtolerated option for metabolic support[3]. This educational protocol outlines a onceโdaily subcutaneous approach using a practical dilution for clear insulinโsyringe measurements.
- 5 mg Vial Reconstitution: Add 3.0 mL bacteriostatic water โ ~1.667 mg/mL (1667 mcg/mL) concentration.
- 2 mg Vial Reconstitution: Add 3.0 mL bacteriostatic water โ ~0.667 mg/mL (667 mcg/mL) concentration.
- Typical daily range: 300โ500 mcg once daily (gradual titration).
- Easy measuring: At 1.667 mg/mL, 1 unit = 0.01 mL โ 16.7 mcg; at 0.667 mg/mL, 1 unit = 0.01 mL โ 6.7 mcg.
- Storage: Lyophilized: freeze at โ20 ยฐC (โ4 ยฐF); after reconstitution, refrigerate at 2โ8 ยฐC (35.6โ46.4 ยฐF); avoid freezeโthaw cycles.
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Approach (Both Vials)
| Week | Daily Dose (mcg) | 5 mg Vial (Units) | 2 mg Vial (Units) |
|---|---|---|---|
| Weeks 1โ4 | 300 mcg | 18 units (0.18 mL) | 45 units (0.45 mL) |
| Weeks 5โ12 | 500 mcg | 30 units (0.30 mL) | 75 units (0.75 mL) |
Frequency: Inject once daily subcutaneously (typically in the morning on an empty stomach). This schedule uses the largest practical dilution (3.0 mL) to keep perโinjection units manageable for better accuracy. Rotate injection sites (abdomen, thighs, upper arms) to minimize local irritation.
Reconstitution Steps (Both Vials)
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2โ8 ยฐC (35.6โ46.4 ยฐF), protected from light.
Supplies Needed
Plan based on an 8โ12 week daily protocol with gradual titration (300 mcg Weeks 1โ4, 500 mcg Weeks 5+).
For 5 mg Vials
- Peptide Vials (AOD-9604, 5 mg each):
- 8 weeks โ 5 vials
- 12 weeks โ 8 vials
- 16 weeks โ 11 vials
- Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial.
- 8 weeks (5 vials): 15 mL โ 2 ร 10 mL bottles
- 12 weeks (8 vials): 24 mL โ 3 ร 10 mL bottles
- 16 weeks (11 vials): 33 mL โ 4 ร 10 mL bottles
For 2 mg Vials
- Peptide Vials (AOD-9604, 2 mg each):
- 8 weeks โ 12 vials
- 12 weeks โ 19 vials
- 16 weeks โ 26 vials
- Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial.
- 8 weeks (12 vials): 36 mL โ 4 ร 10 mL bottles
- 12 weeks (19 vials): 57 mL โ 6 ร 10 mL bottles
- 16 weeks (26 vials): 78 mL โ 8 ร 10 mL bottles
Common Supplies (Both)
- Insulin Syringes (Uโ100):
- Per week: 7 syringes (1/day)
- 8 weeks: 56 syringes
- 12 weeks: 84 syringes
- 16 weeks: 112 syringes
- Alcohol Swabs: One for the vial stopper + one for the injection site each day.
- Per week: 14 swabs (2/day)
- 8 weeks: 112 swabs โ recommend 2 ร 100โcount boxes
- 12 weeks: 168 swabs โ recommend 2 ร 100โcount boxes
- 16 weeks: 224 swabs โ recommend 3 ร 100โcount boxes
Protocol Overview
Concise summary of the onceโdaily regimen.
- Goal: Support reduction of fat mass and enhance fat oxidation over time[1][4].
- Schedule: Daily subcutaneous injections for 8โ12 weeks (extend to 16 weeks if desired).
- Dose Range: 300โ500 mcg daily with gradual titration.
- Reconstitution: 3.0 mL per vial for accurate unit measurements.
- Storage: Lyophilized frozen; reconstituted refrigerated; avoid repeated freezeโthaw.
Dosing Protocol
Suggested daily titration approach.
- Start: 300 mcg daily for Weeks 1โ4; increase to 500 mcg for Weeks 5โ12 as tolerated.
- Target: 500 mcg daily by Week 5 and maintain through cycle completion.
- Frequency: Once per day (subcutaneous).
- Cycle Length: 8โ12 weeks; optional extension to 16 weeks.
- Timing: Morning administration (fasted) is common; rotate injection sites.
Storage Instructions
Proper storage preserves peptide quality.
- Lyophilized: Store at โ20 ยฐC (โ4 ยฐF) in dry, dark conditions; stable for 1+ year[5].
- Reconstituted: Refrigerate at 2โ8 ยฐC (35.6โ46.4 ยฐF); use within 3โ4 weeks and avoid freezeโthaw[6].
- Allow vials to reach room temperature before opening to reduce condensation uptake.
Important Notes
Practical considerations for consistency and safety.
- Use new sterile insulin syringes (Uโ100, 29โ31 gauge); dispose in a sharps container[7].
- Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation and prevent lipohypertrophy[8].
- Inject slowly; wait a few seconds before withdrawing the needle.
- 5 mg vial: Provides ~10 days at 500 mcg/day or ~16โ17 days at 300 mcg/day.
- 2 mg vial: Provides ~4 days at 500 mcg/day or ~6โ7 days at 300 mcg/day.
- For โค10-unit (โค0.10 mL) administrations, consider 30- or 50-unit insulin syringes for improved readability.
How This Works
AODโ9604 is a modified Cโterminal fragment of human growth hormone that retains the lipolytic (fatโreducing) domain without the growthโpromoting effects[1]. It binds to adipose tissue and triggers breakdown of stored fat while blocking new fat storage (reโesterification) in adipocytes[4]. At the molecular level, chronic AODโ9604 administration upregulates ฮฒ3โadrenergic receptors in fat tissue, reversing obesityโrelated suppression of these fatโburning receptors[9]. Unlike fullโlength hGH, AODโ9604 does not meaningfully elevate IGFโ1 levels or worsen glucose tolerance, making its tolerability indistinguishable from placebo in human trials[2][3].
Potential Benefits & Side Effects
Observations from preclinical and clinical literature.
- Supports reductions in fat mass and increases in fat oxidation over time; clinical trials showed modest but statistically significant weight loss (approximately 2.6 kg vs. 0.8 kg placebo over 12 weeks at 1 mg/day)[10].
- Preferential loss of abdominal fat observed, resembling the pattern seen with lowโdose hGH therapy[10].
- Does not meaningfully raise IGFโ1 and shows a placeboโlike safety profile in human studies; no antiโAOD9604 antibodies detected[2][3].
- Emerging regenerative potential: preclinical studies suggest possible cartilage repair and bone health benefits[11][12].
- Generally well tolerated; occasional mild injectionโsite reactions (redness/itch) may occur with subcutaneous administration.
Lifestyle Factors
Complementary strategies for best outcomes.
- Pair with a hypocaloric, proteinโforward diet tailored to energy needs; AODโ9604 is best viewed as a supportive aid to fat loss rather than a standโalone solution[10].
- Combine resistance training and aerobic activity to reinforce metabolic adaptations.
- Prioritize sleep and stress management to support adherence and recovery.
Injection Technique
General subcutaneous guidance from clinical bestโpractice resources[7].
- Clean the vial stopper and skin with alcohol; allow to dry completely[8].
- Pinch a skinfold; insert the needle at 90ยฐ (or 45ยฐ if very little subcutaneous fat) into subcutaneous tissue[7].
- Do not aspirate for subcutaneous injections; inject slowly and steadily[13].
- Rotate sites systematically (abdomen at least 2 inches from navel, thighs, upper arms) to avoid lipohypertrophy[8].
- Using a 30- or 50-unit insulin syringe improves accuracy when measuring small volumes.
Recommended Source
We recommend Shop Peptides Direct for highโpurity AOD-9604 (2 mg & 5 mg).
Why Shop Peptides Direct?
- Highโpurity, thirdโpartyโtested lots with batch COAs.
- Consistent, ISOโaligned handling and documentation.
- Reliable fulfillment to maintain coldโchain integrity.
Important Note
This content is intended for therapeutic educational purposes only and does not constitute medical advice, diagnosis, or treatment. AOD-9604 is for research use only. Not for human consumption. Always consult with qualified professionals before starting any peptide research protocol.
References
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Journal of Endocrinology and Metabolism (2014) โ Safety and metabolism of AOD9604 as a nutraceutical ingredient; mechanism of action and metabolic studies
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Journal of Endocrinology and Metabolism (2013) โ Safety and tolerability of AOD9604 in humans; no IGFโ1 increase; placeboโlike safety profile
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FDA Pharmacy Compounding Advisory Committee (2024) โ AODโ9604 bulk drug substance meeting memorandum; regulatory and safety overview
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Endocrinology (OUP) โ Effects of hGH and AOD9604 on lipid metabolism in obese mice; ฮฒโadrenergic pathway mechanisms
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Bachem Peptide Guide โ Handling and storage guidelines for peptides; lyophilized stability recommendations
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Creative Peptides โ Peptide stability and shelf life; reconstituted solution storage guidelines
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MedlinePlus Medical Encyclopedia (NIH) โ Subcutaneous injection patient instructions; technique and site guidance
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Olympia Pharmacy โ How to administer a subcutaneous injection; site rotation and hygiene
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Endocrinology (OUP) โ Chronic AOD9604 treatment in obese and ฮฒ3โAR knockout mice; receptor upregulation
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Gastroenterology โ Drug treatment of the overweight patient; AODโ9604 RCT summary and clinical efficacy
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Annals of Clinical and Laboratory Science (PubMed) โ Effect of intraโarticular AOD9604 with hyaluronic acid in rabbit osteoarthritis model
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DrugBank โ AOD9604 drug summary; mechanism of action, bone and metabolic effects
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CDC โ Vaccine administration: subcutaneous route; no aspiration required
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