Epitalon (Epithalon)
Epitalon is a synthetic tetrapeptide studied for its ability to activate telomerase. By maintaining telomere length, it is key for research into cellular health and longevity models.
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Epitalon (also known as Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally developed by the St. Petersburg Institute of Bioregulation and Gerontology. It has gained interest for its reported ability to activate telomerase, an enzyme that maintains the length and integrity of telomeres—the protective caps on the ends of chromosomes. By preventing telomere shortening, Epitalon is under investigation for its potential role in longevity, cellular health, and age-related disease models.
– Form: Lyophilized peptide
– Purity: >99%
– Origin: Manufactured and lab-tested in the USA
– Documentation: Certificate of Analysis (COA) included
Epitalon activates the enzyme telomerase in somatic cells, which helps repair and extend telomeres. By maintaining telomere length, cells can divide more times before reaching senescence, which may delay cellular aging. It may also modulate melatonin secretion and antioxidant activity, contributing to circadian rhythm regulation and oxidative stress defense.
– Longevity and aging models
– Telomere biology and chromosomal stability
– Age-related disease research
– Cellular senescence and DNA repair studies
– Pineal gland and circadian rhythm modulation
– Promotes telomere stability and length
– Supports cell longevity and genomic integrity
– Exhibits antioxidant and melatonin-modulating properties
– Ideal for aging and DNA-repair-based research models
Each vial is:
– Produced in a GMP-compliant U.S. facility
– Accompanied by a Certificate of Analysis (COA)
– Verified via HPLC and mass spectrometry
– Shipped securely with quality-control documentation
– Contents: 10mg Epitalon lyophilized peptide
– Appearance: White to off-white crystalline powder
– Solubility: Reconstitute with sterile bacteriostatic water
– Storage: Store lyophilized at -20°C; refrigerate after reconstitution and use within 30 days
*For research use only. Not for human or veterinary consumption.*
– Intended for laboratory research only
– Not approved for human consumption or clinical use
– Buyer assumes all responsibility for research use and compliance
Its potential ability to activate telomerase sets it apart, making it valuable in telomere biology and anti-aging studies.
Unlike many peptides focused on hormone pathways, Epitalon targets DNA integrity via telomere maintenance.
When properly stored, Epitalon remains stable for long-term research use. After reconstitution, it is best used within 30 days.
Yes. All batches undergo purity, identity, and stability testing and are shipped with a full COA.
Epitalon (Epithalon) (10 mg Vial) Dosage Protocol
Quickstart Highlights
Epitalon (Epithalon) dosage protocols center on this synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from pineal gland research for its geroprotective potential[1]. Epitalon activates telomerase to promote telomere elongation, supports healthy melatonin production for improved sleep and circadian rhythm regulation, and has demonstrated lifespan extension in animal models[2][3]. Human studies suggest potential benefits for longevity, cardiovascular health, and physiological function in older adults[4]. This educational protocol presents a once-daily subcutaneous approach using a practical dilution for clear insulin-syringe measurements.
- Reconstitute: Add 2.0 mL bacteriostatic water → 5 mg/mL concentration.
- Typical daily dose: 5,000 mcg (5 mg) once daily for 20 consecutive days.
- Easy measuring: At 5 mg/mL, 1 unit = 0.01 mL = 50 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard Protocol (2 mL = 5 mg/mL)
| Phase | Daily Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Days 1–20 (Cycle On) | 5,000 mcg (5 mg) | 100 units (1.00 mL) |
| Weeks 4–26 (Cycle Off) | 0 mcg | — |
Frequency: Inject once daily subcutaneously, preferably in the evening or at bedtime to synergize with natural melatonin rhythms[3]. Complete 20 consecutive days, then observe a 4–6 month off-cycle before repeating (typically 2 cycles per year)[5].
Alternative Approach: Some protocols use 10 mg/day for 10 days (same total cycle dose of 100 mg). This requires reconstitution with 1.0 mL bacteriostatic water to create a 10 mg/mL concentration, where 1 unit = 0.01 mL = 100 mcg.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe for standard 5 mg/mL concentration.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label with reconstitution date and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Supplies Needed
Plan based on a 20-day daily protocol at 5 mg/day.
- Peptide Vials (Epitalon, 10 mg each):
- 20-day cycle (5 mg/day): 10 vials (each vial yields 2 doses)
- Alternative 10-day cycle (10 mg/day): 10 vials (each vial yields 1 dose)
- Insulin Syringes (U-100, 1 mL capacity):
- Per 20-day cycle: 20 syringes (1/day)
- Per 10-day cycle: 10 syringes (1/day)
- Bacteriostatic Water (10 mL bottles): Use 2.0 mL per vial for standard reconstitution (5 mg/mL).
- 20-day cycle (10 vials): 20 mL → 2 × 10 mL bottles
- Alternative: Use 1.0 mL per vial for 10 mg/mL concentration
- Alcohol Swabs: One for the vial stopper + one for the injection site each day.
- 20-day cycle: 40 swabs (2/day) → recommend 1 × 100-count box
- 10-day cycle: 20 swabs (2/day)
Protocol Overview
Concise summary of the once-daily regimen.
- Goal: Support telomere maintenance, melatonin regulation, and geroprotective effects over time[2].
- Schedule: Daily subcutaneous injections for 20 consecutive days, followed by 4–6 months off-cycle.
- Dose: 5,000 mcg (5 mg) daily (standard) or 10,000 mcg (10 mg) daily (alternative).
- Reconstitution: 2.0 mL per 10 mg vial (5 mg/mL) for standard dosing; 1.0 mL per vial for 10 mg/mL concentration.
- Storage: Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.
Dosing Protocol
Suggested daily approach based on published research protocols.
- Standard Dose: 5,000 mcg (5 mg) once daily subcutaneously[5] for 20 consecutive days.
- Alternative: 10,000 mcg (10 mg) once daily for 10 days (same total cycle dose of 100 mg).
- Frequency: Once per day (subcutaneous), preferably at bedtime.
- Cycle Length: 20 days on (standard) or 10 days on (alternative), then 4–6 months off.
- Timing: Evening administration recommended; rotate injection sites daily.
Storage Instructions
Proper storage preserves peptide quality.
- Lyophilized: Store at −20 °C (−4 °F) for long-term; refrigerate at 2–8 °C (35.6–46.4 °F) for routine storage; minimize moisture exposure[6].
- Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); use within 2–4 weeks and avoid freeze–thaw[7].
- Allow vials to reach room temperature before opening to reduce condensation uptake.
- Protect from light; wrap vials in foil or store in opaque container.
Important Notes
Practical considerations for consistency and safety.
- Use new sterile insulin syringes for each injection; dispose in a sharps container.
- Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation[8].
- Inject slowly; wait a few seconds before withdrawing the needle.
- Document daily dose and site rotation to maintain consistency.
- Reconstitute one vial at a time (every 1-2 days) to keep solutions fresh.
- Evening administration is preferred to align with natural melatonin production cycles.
How This Works
Epitalon's primary mechanism involves telomerase activation, promoting telomere elongation in cells[2]. In vitro studies demonstrated that Epitalon induced telomerase and lengthened telomeres in human cell cultures, allowing cells to continue dividing beyond the usual Hayflick limit[9]. Epitalon also influences the neuroendocrine system by stimulating nocturnal melatonin release from the pineal gland, thereby normalizing circadian hormone rhythms in aged subjects[3]. Additional reported effects include antioxidant activity, genomic regulatory effects, and immune modulation[1].
Human clinical studies have shown promising results, including a 12-year randomized controlled trial demonstrating improved cardiovascular outcomes and reduced mortality in elderly subjects with accelerated aging[4]. Animal models have shown lifespan extension and reduced tumor incidence with Epitalon administration[1].
Potential Benefits & Side Effects
Observations from preclinical and clinical literature.
- Supports telomere maintenance and cellular longevity through telomerase activation[2][9].
- Restores healthy melatonin production and circadian rhythm regulation[3].
- Extended lifespan and reduced tumor incidence observed in animal models[1].
- Human trials showed improved cardiovascular outcomes and reduced mortality over 12-year follow-up[4].
- Generally well tolerated; no serious adverse events reported in long-term studies[5].
- Occasional mild injection-site reactions or transient sleep pattern changes may occur.
- Effects are cumulative over cycles; benefits may become more apparent with repeated annual protocols.
Lifestyle Factors
Complementary strategies for best outcomes.
- Prioritize sleep hygiene and maintain consistent sleep-wake schedules to complement melatonin effects.
- Pair with a balanced, antioxidant-rich diet to support cellular health and reduce oxidative stress.
- Engage in regular physical activity to reinforce metabolic and cardiovascular adaptations.
- Manage stress through mindfulness or relaxation techniques to support circadian balance.
- Maintain healthy body composition and metabolic parameters to support longevity pathways.
- Consider complementary supplements like melatonin (low dose), NAD+ precursors, or antioxidants.
Injection Technique
General subcutaneous guidance from clinical best-practice resources[8][10][11].
- Clean the vial stopper and skin with alcohol; allow to dry completely.
- Pinch a skinfold; insert the needle at 45–90° into subcutaneous tissue[10][11].
- Do not aspirate for subcutaneous injections; inject slowly and steadily[10].
- Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy[8].
- Withdraw the needle at same angle; apply gentle pressure with clean gauze.
- Dispose of used syringes immediately in a proper sharps container.
- Maintain at least 1–2 inches between injection sites to prevent tissue irritation.
Recommended Source
We recommend Shop Peptides Direct for high-purity Epitalon (10 mg).
Why Shop Peptides Direct?
- High-purity, third-party-tested lots with batch Certificates of Analysis (COAs).
- Consistent, ISO-aligned handling and comprehensive documentation.
- Reliable fulfillment with proper cold-chain management to maintain peptide integrity.
- Transparent sourcing and quality control procedures for research-grade peptides.
Important Note
This content is intended for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Epitalon is for research use only and not intended for human consumption. Always consult with qualified healthcare professionals before considering any peptide protocol. This information is provided for research and educational purposes only.
References
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Int J Mol Sci (MDPI) — Overview of Epitalon: Highly Bioactive Pineal Tetrapeptide with Promising Properties (2025)
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PMC/Biogerontology — Epitalon increases telomere length in human cell lines through telomerase upregulation
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Neuroendocrinology Letters (PubMed) — Synthetic tetrapeptide Epitalon restores neuroendocrine regulation in senescent monkeys
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Bull Exp Biol Med (PubMed) — Geroprotective effect of epithalamine in elderly with accelerated aging (12-year RCT)
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Alzheimer's Drug Discovery Foundation — Epithalamin/Epitalon Cognitive Vitality Report (mechanisms, dosing, safety)
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JPT Peptide Technologies — Peptide Stability: How Long Do Peptides Last? (storage best practices)
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Tydes Laboratory — Bacteriostatic Water and Peptide Reconstitution (28-day use guideline)
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Johns Hopkins Arthritis Center — How to Give a Subcutaneous Injection (patient education guide)
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Wikipedia — Epitalon (overview of Hayflick limit studies and telomerase activation)
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CDC — Vaccine administration: subcutaneous route (angle/site; no aspiration)
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Immunize.org (IAC) — How to Administer Subcutaneous Injections (CDC-backed guidelines)
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