PT-141 (Bremelanotide)
PT-141 (Bremelanotide) is an ฮฑ-MSHย peptide analog that enhances libido and sexual function. It works directly on the central nervous system to stimulate sexual desire, making it vital for research on sexual dysfunction and performance.
$33.99
-
Official retailer
-
Quality guaranteed
-
Within 2 Days Delivery
-
99% Purified
PT-141 (Bremelanotide) is a synthetic peptide analog of ฮฑ-MSH studied for its role in enhancing libido and sexual function. Unlike other agents that act on the vascular system, PT-141 works directly on the central nervous system to stimulate sexual desire. It has been a subject of interest in preclinical and animal studies related to sexual dysfunction, performance, and behavioral stimulation.
โ Form: Lyophilized peptide
โ Purity: >99%
โ Origin: USA-tested, COA included
โ Storage: Store at -20ยฐC dry, refrigerate after reconstitution
PT-141 functions as a melanocortin receptor agonist (primarily MC3R and MC4R), targeting brain regions involved in arousal and sexual motivation. This neuroendocrine pathway activation increases libido and responsiveness independent of vascular effects, making it unique among compounds studied for sexual function.
โ Sexual motivation and performance models
โ Libido and arousal research
โ Neurobehavioral pathways of sexual function
โ Central nervous system mechanism of action
โ Targets melanocortin pathways
โ Useful in models of arousal, desire, and sexual performance
Each vial is:
โ Produced in a GMP-compliant U.S. facility
โ Verified for purity via HPLC and MS analysis
โ Shipped with Certificate of Analysis (COA)
โ Contents: 10mg PT-141 lyophilized peptide per vial
โ Appearance: White powder
โ Solubility: Reconstitute with bacteriostatic water
โ Storage: Store at -20ยฐC dry; refrigerate post-mixing and use within 30 days
*For laboratory research only. Not for human consumption.*
โ For research use only
โ Not for human or veterinary use
โ Buyer assumes all responsibility for proper usage
Unlike PDE5 inhibitors, PT-141 works through central nervous system pathways, not vascular mechanisms.
Yes, PT-141 has been studied in both male and female animal models of sexual motivation and dysfunction.
Each batch is >99% pure and comes with full COA documentation.
Once reconstituted, it should be refrigerated and used within 30 days for best results.
PT-141 (10 mg Vial) Dosage Protocol
Quickstart Highlights
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist (MC3R/MC4R) derived from Melanotan II[1]. It was FDA-approved in 2019 for hypoactive sexual desire disorder (HSDD) in premenopausal women[2]. Unlike PDE5 inhibitors, PT-141 acts centrally to enhance sexual desire by increasing dopamine release in brain reward and arousal regions[3]. This educational protocol presents on-demand subcutaneous administration using a practical dilution for clear insulin-syringe measurements.
- Reconstitute: Add 3.0 mL bacteriostatic water โ ~3.33 mg/mL concentration.
- FDA-approved dose: 1.75 mg (1750 mcg) at least 45 minutes before anticipated activity.
- Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL โ 33.3 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at โ20 ยฐC (โ4 ยฐF); after reconstitution, refrigerate at 2โ8 ยฐC (35.6โ46.4 ยฐF); avoid freezeโthaw cycles.
Dosing & Reconstitution Guide
Educational guide for reconstitution and on-demand dosing
On-Demand Protocol (3 mL = ~3.33 mg/mL)
| Use Case | Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Standard (FDA-approved) | 1750 mcg (1.75 mg) | 53 units (0.53 mL) |
| Lower Starting Dose | 1000 mcg (1.0 mg) | 30 units (0.30 mL) |
| Conservative Start | 500 mcg (0.5 mg) | 15 units (0.15 mL) |
Frequency: Inject subcutaneously at least 45 minutes before anticipated sexual activity[2]. Maximum: One injection per 24 hours; no more than 8 injections per month[3]. For doses โค15 units (โค0.15 mL), consider 30- or 50-unit insulin syringes for improved readability.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2โ8 ยฐC (35.6โ46.4 ยฐF), protected from light.
Supplies Needed
Plan based on on-demand use (up to 8 doses/month) or extended daily protocols.
- Peptide Vials (PT-141, 10 mg each):
- On-demand (8 doses/month at 1.75 mg): 2 vials per month
- 16-week daily protocol: ~10 vials
- Insulin Syringes (U-100):
- On-demand (8/month): 8 syringes per month
- 16-week daily: 112 syringes
- Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
- On-demand (2 vials): 6 mL โ 1 ร 10 mL bottle
- 16-week daily (10 vials): 30 mL โ 3 ร 10 mL bottles
- Alcohol Swabs: One for the vial stopper + one for the injection site each use.
- On-demand (8/month): 16 swabs per month
- 16-week daily: 224 swabs โ recommend 3 ร 100-count boxes
Protocol Overview
Concise summary of the on-demand regimen.
- Goal: Support sexual desire and arousal through central melanocortin receptor activation[3].
- Schedule: On-demand subcutaneous injection โฅ45 minutes before anticipated activity.
- Dose: 1.75 mg (1750 mcg) per the FDA-approved regimen[2].
- Limits: Maximum once per 24 hours; no more than 8 doses per month[3].
- Reconstitution: 3.0 mL per 10 mg vial (~3.33 mg/mL) for accurate unit measurements.
Dosing Protocol
Suggested on-demand approach.
- Standard Dose: 1.75 mg (53 units) subcutaneously.
- Timing: At least 45 minutes before anticipated sexual activity[2].
- Frequency: No more than once every 24 hours.
- Monthly Limit: Maximum 8 injections per month[3].
- Route: Subcutaneous (abdomen or thigh); rotate injection sites.
Storage Instructions
Proper storage preserves peptide quality.
- Lyophilized: Store at โ20 ยฐC (โ4 ยฐF) in dry, dark conditions; minimize moisture exposure[9].
- Reconstituted: Refrigerate at 2โ8 ยฐC (35.6โ46.4 ยฐF); use within approximately 30 days; avoid freezeโthaw.
- Allow vials to reach room temperature before opening to reduce condensation uptake.
Important Notes
Practical considerations for consistency and safety.
- Use new sterile insulin syringes; dispose in a sharps container[7].
- Rotate injection sites (abdomen, thighs) to reduce local irritation[6].
- Inject slowly; wait a few seconds before withdrawing the needle.
- PT-141 may cause transient blood pressure elevation; avoid use in uncontrolled hypertension[3].
- Nausea is the most common side effect; it is typically mild and transient[3].
How This Works
Bremelanotide (PT-141) is a synthetic analog of ฮฑ-melanocyte-stimulating hormone (ฮฑ-MSH), acting as a non-selective melanocortin receptor agonist with predominant activity at MC3R and MC4R[3]. In the central nervous system, MC4R activation leads to enhanced dopamine release in key brain reward and arousal regionsโincluding the nucleus accumbens and medial preoptic areaโwhich increases sexual motivation and desire[3]. Unlike PDE5 inhibitors (e.g., sildenafil), PT-141 does not directly affect the nitric oxide pathway; in males, its pro-erectile effect is secondary to central mechanisms stimulating nitric oxide production in penile tissue[3]. Peripheral MC1R agonism accounts for side effects such as transient blood pressure elevation and skin hyperpigmentation[3].
Potential Benefits & Side Effects
Observations from clinical literature.
- Benefits: Clinical trials in premenopausal women with HSDD showed PT-141 significantly improves sexual desire scores (FSFI-Desire) and reduces distress (FSDS-DAO) versus placebo[3].
- Early studies in men demonstrated improved erectile responses with intranasal PT-141[1].
- Common Side Effects: Nausea (~40%), flushing (~20%), headache (~11%); these are typically mild and transient[3].
- Other Effects: Transient blood pressure elevation, skin hyperpigmentation with repeated use[3].
- Subcutaneous administration provides ~100% bioavailability and is better tolerated than intranasal delivery[3].
Lifestyle Factors
Complementary strategies for best outcomes.
- Maintain open communication with partners about expectations and timing.
- Address underlying contributors to low desire (stress, relationship factors, hormonal status).
- Limit alcohol consumption, which may blunt response or worsen nausea.
- Ensure adequate sleep and stress management to support overall sexual health.
Injection Technique
General subcutaneous guidance from clinical best-practice resources[7].
- Clean the vial stopper and skin with alcohol; allow to dry[7].
- Pinch a skinfold; insert the needle at 45โ90ยฐ into subcutaneous tissue[7][8].
- Do not aspirate for subcutaneous injections; inject slowly and steadily[7].
- Rotate sites systematically (abdomen, thighs) to avoid lipohypertrophy[6].
- Discard needles and syringes after single use[7].
Recommended Source
We recommend Shop Peptides Direct for high-purity PT-141 (10 mg).
Why Shop Peptides Direct?
- High-purity, third-party-tested lots with batch COAs.
- Consistent, ISO-aligned handling and documentation.
- Reliable fulfillment to maintain cold-chain integrity.
Important Note
This content is for educational purposes only and is not medical advice. PT-141 is for research use only. Not for human consumption. Always consult with qualified professionals before starting any peptide research protocol.
References
-
ScienceDirect โ Bremelanotide overview: pharmacology, Melanotan II derivative, early clinical data
-
FDA Label โ Vyleesi (bremelanotide) โ Full prescribing information: 1.75 mg SC, timing, frequency limits
-
PMC โ Bremelanotide for Treatment of Female Hypoactive Sexual Desire โ Mechanism, clinical trial outcomes, safety profile, bioavailability
-
ResearchGate โ Effect of bremelanotide on body weight of obese women โ Phase 1 RCTs: 2.5 mg daily dosing for metabolic endpoints
-
Mayo Clinic โ Bremelanotide (Subcutaneous Route) โ Patient information, side effects, proper use guidance
-
MedlinePlus โ Subcutaneous Injection Instructions โ Site rotation, technique, and patient education
-
CDC โ Subcutaneous Injection Administration โ Technique, angle, aseptic procedure, no aspiration required
-
CDC โ Vaccine Administration: During โ General injection guidance including subcutaneous route
-
CDC โ Storage and Handling of Immunobiologics โ Cold-chain principles applicable to lyophilized peptides
-
NCBI Bookshelf โ Injection Best Practices โ Asepsis, preparation, and administration techniques
-
PMC โ Subcutaneous Drug Injection Review โ Pharmacologic considerations of the subcutaneous route
RELATED PRODUCTS
GHK-Cu
View Certificate
Melanotan II
GHRP-2
Reviews
There are no reviews yet.